Quviviq (dazodalant) is an innovative insomnia treatment that is unique in its novel mechanism of action.

Unlike traditional sleep aids, Quviviq does not induce sleep by depressing the central nervous system, but rather by precisely targeting the body's biological clock.

The body's biological clock is like an internal clock that regulates our daily sleep and wake-up cycles. When this biological clock is disrupted, sleep problems such as insomnia often follow.

Quviviq helps to recalibrate the biological clock by regulating specific neurotransmitters and signalling pathways, allowing the body to naturally enter and maintain a good state of sleep.

Quviviq's Mechanism of Action: Precise Regulation of “Wakefulness Signalling”

Quviviq's mechanism of action is very different from that of traditional sleeping pills (e.g. benzodiazepines).

Instead of directly depressing the central nervous system, Quviviq targets orexin type receptors (OX1R) and type receptors (OX2R), blocking the action of wakefulness-promoting neuropeptides (orexins A and B), thereby reducing hyperarousal in the brain.

This mechanism allows Quviviq to improve sleep without significantly affecting the structure of the sleep, and with a lower hangover effect on the next day, reducing the daytime sleepiness commonly associated with traditional sleeping pills.

This mechanism allows Quviviq to improve sleep without significantly affecting sleep architecture and with a lower next-day hangover effect, reducing the side effects of daytime sleepiness and cognitive decline commonly associated with traditional sleeping pills.

Global and Chinese Clinical Data: Significantly Improves Sleep Quality And Daytime Function

Quviviq has been approved for marketing in the U.S., EU, and Japan, and its efficacy and safety are supported by multiple Phase III clinical trials.

Global data: Two pivotal Phase III studies (enrolling a total of 1,854 patients) demonstrated that Quviviq (25mg and 50mg dosages) significantly shortened the time to sleep (LPS), reduced the number of nocturnal awakenings (WASO), and prolonged the total sleep time (sTST) compared to placebo.

Notably, Quviviq is currently the only drug in the DORA class approved by the European Medicines Agency (EMA) to improve daytime functioning, meaning that it not only helps patients fall asleep, but also reduces the impact of insomnia on daytime work, mood and quality of life.

Looking Ahead: A New Era Of Insomnia Treatment

Quviviq's marketing application marks the entry of insomnia treatment in China into the era of precision targeting.

In the future, with the introduction of more DORA-like drugs, insomnia patients will have safer and more effective treatment options.

However, how to balance the high cost of innovative drugs with the affordability of health insurance is still a challenge for the industry to solve.

Market Availability And Insurance Coverage

Quviviq was launched in the U.S. in May 2022, followed by European countries such as Italy and Germany.

Additionally, in November 2022, Idorsia announced that Quviviq was covered by the U.S. military health insurance (TRICARE), further expanding patient accessibility.

In Summary

Clinical data on Quviviq shows that it not only improves nighttime sleep but also enhances daytime functioning, offering new hope for patients with chronic insomnia.

With the regulatory approval in China moving forward, this innovative drug is expected to officially land on the Chinese market in 2025-2026, transforming the quality of life for hundreds of millions of insomnia patients.

However, DengYue’s efforts to increase the affordability of the medicine are critical to ensuring that more patients benefit from it.

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