Having several weapons in Resident Evil Requiem does not mean you should simply use whichever gun deals the most damage. When playing as Leon S. Kennedy, choosing the right weapon for the distance, enemy type, and available ammunition can make combat much more efficient.

The goal is to avoid spending valuable ammunition on situations that could have been handled with cheaper options.

What Should You Use Against Regular Enemies?
For ordinary encounters, start with your most sustainable firearm rather than immediately using high-damage ammunition.

Basic enemies are often more of a resource-management problem than a raw damage problem. If you spend premium ammunition every time something appears in a hallway, you may have very little remaining when a tougher enemy arrives.

Accuracy also matters.

Take controlled shots whenever the situation allows rather than firing rapidly without confirming your aim.

What Should You Do at Close Range?
Close-range encounters require quick decisions.

If an enemy is already approaching Leon, continuing to aim carefully while standing still may be dangerous. Your immediate goal should be creating enough space to regain control.

Use an appropriate firearm to interrupt the threat when possible, then reposition.

Once you have created a safe opening, Leon's hatchet may provide an opportunity to deal additional damage without spending more ammunition.

However, check the surroundings before committing to melee.

A safe hatchet opportunity against one enemy can become dangerous if another creature is approaching from behind.

Which Weapons Should You Save?
High-damage weapons become more valuable against tougher enemies and bosses.

Instead of asking which weapon does the most damage, ask:

Which enemy actually deserves this ammunition?
If an ordinary enemy can be handled safely with standard rounds, using stronger ammunition provides limited benefit.

Save your heavier options for enemies that take substantial punishment, present an immediate threat, or expose short damage opportunities where powerful attacks have greater value.

When Should You Switch Weapons?
Do not wait until your current weapon is completely useless before switching.

Imagine that an enemy has closed the distance while you are holding a weapon better suited to careful long-range attacks. Trying to maintain the same strategy may allow the enemy to reach Leon.

Switch according to the situation.

A useful mindset is:

Longer distance → accuracy and controlled damage

Medium distance → reliable sustained attacks

Close distance → immediate stopping power or safe melee opportunities

The exact weapon changes according to what you currently have available, but the principle remains the same.

How Should You Manage Ammunition?
Avoid evaluating ammunition only by the number displayed in your inventory.

Think about what each type of ammunition is supposed to accomplish.

Twenty rounds for a powerful weapon may actually represent more combat value than a much larger supply of weaker ammunition. Conversely, wasting one strong round on an easy enemy may be more expensive than spending several basic rounds.

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Should You Reload Every Weapon Before Exploring?
Before entering a major unexplored area, check the weapons you expect to use.

A partially empty magazine is not always a problem, but entering a suspicious room with only one shot loaded can force an emergency reload at the worst possible moment.

Reload when the environment is safe.

During combat, use moments when enemies are staggered, distant, or temporarily unable to attack.

Final Thoughts
Weapon management in Resident Evil Requiem is about efficiency rather than maximum damage.

Use sustainable firearms against ordinary threats, reserve powerful ammunition for enemies that justify it, switch weapons when combat distance changes, and use Leon's hatchet when a genuinely safe opportunity appears.

The better you match your weapon to the situation, the more resources you will have available when the game becomes significantly more dangerous.